Target validation using chemical probes.
نویسندگان
چکیده
Fully profiled chemical probes are essential to support the unbiased interpretation of biological experiments necessary for rigorous preclinical target validation. We believe that by developing a ‘chemical probe tool kit’, and a framework for its use, chemical biology can have a more central role in identifying targets of potential relevance to disease, avoiding many of the biases that complicate target validation as practiced currently.
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ورودعنوان ژورنال:
- Nature chemical biology
دوره 9 4 شماره
صفحات -
تاریخ انتشار 2013